From: MECHANISMS OF EPILEPTOGENESIS
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چکیده
منابع مشابه
Pathogenesis of Epilepsy: Challenges in Animal Models
Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, severa...
متن کاملElectrophysiological aspects of interictal and ictal activity in human partial epilepsy
Considerable attention has been paid in recent times to cellular and synaptic mechanisms involved in epileptogenesis. A number of in vivo and in vitro animal models are now available to study basic mechanisms of epileptogenesis and to select and evaluate antiepileptic compounds which could be potentially effective in human epilepsy. Although this approach has been useful for practical purposes,...
متن کاملHomeostatic control of brain function – new approaches to understand epileptogenesis
Neuronal excitability of the brain and ongoing homeostasis depend not only on intrinsic neuronal properties, but also on external environmental factors; together these determine the functionality of neuronal networks. Homeostatic factors become critically important during epileptogenesis, a process that involves complex disruption of self-regulatory mechanisms. Here we focus on the bioenergetic...
متن کاملEpigenetics of Epileptogenesis-Evoked Upregulation of Matrix Metalloproteinase-9 in Hippocampus
Enhanced levels of Matrix Metalloproteinase-9 (MMP-9) have been implicated in the pathogenesis of epilepsy in humans and rodents. Lack of Mmp-9 impoverishes, whereas excess of Mmp-9 facilitates epileptogenesis. Epigenetic mechanisms driving the epileptogenesis-related upregulation of MMP-9 expression are virtually unknown. The aim of this study was to reveal these mechanisms. We analyzed hippoc...
متن کاملDoes acquired epileptogenesis in the immature brain require neuronal death.
Because epilepsy often occurs during development, understanding the mechanisms by which this process takes place (epileptogenesis) is important. In addition, the age-specificity of seizures and epilepsies of the neonatal, infancy, and childhood periods suggests that the processes and mechanisms that culminate in epilepsy might be age specific as well. Here we provide an updated review of recent...
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